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Teva Reports TEV 408 Trial Shows Reduced Gluten-Induced Intestinal Damage

Teva Pharmaceutical Industries logoTeva Pharmaceutical Industries
Sig2.85Sen+4.60Env0.00Soc+3.70Gov+0.20

Teva reported encouraging topline results from an active Phase 2a trial of TEV 408, an anti–interleukin-15 monoclonal antibody, for celiac disease. The investigational treatment significantly prevented gluten-related intestinal damage versus placebo at eight weeks. Symptoms and biopsy measures tracked inflammation and structure; after the gluten challenge, TEV 408 showed a clinically meaningful protective effect, with minimal change in intraepithelial lymphocyte density.

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