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Polaryx Appoints Will Charlton CMO Ahead of Phase 2 SOTERIA Trial

Polaryx Therapeutics logoPolaryx Therapeutics
Sig3.12Sen+3.02Env0.00Soc+1.42Gov+1.17

Polaryx Therapeutics appointed Will Charlton, M.D., M.A.S., as chief medical officer to lead clinical strategy for its lead candidate, PLX-200. He will oversee the Phase 2 SOTERIA open-label, single-arm basket trial assessing safety, tolerability and clinical activity in CLN2, CLN3, Krabbe and Sandhoff disease patients. The FDA issued a safe-to-proceed letter for SOTERIA in October 2025, and trial data are expected to guide subsequent development. The company plans to start the study in Q4 2026.

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