Novartis Pelacarsen Fails to Cut Cardiovascular Events in Phase 3
Pelacarsen lowered lipoprotein(a) in Novartis’ Phase 3 Lp(a)HORIZON study but did not achieve a statistically significant reduction in cardiovascular events. BofA called the outcome disappointing yet contained, keeping a Buy rating and $185 target while investors focus on four other Phase 3 readouts expected in 2H 2026. Novartis reported 39 Phase 3 projects and three programs in registration.