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Novartis Lp(a) Drug Pelacarsen Fails Phase 3 Cardio Outcomes Trial

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Sig3.49Sen-3.31Env0.00Soc-0.23Gov+0.29

Novartis shares fell after its Lp(a)-targeted drug pelacarsen failed to reduce cardiovascular risk in a major phase 3 trial, despite lowering Lp(a) levels in Lp(a)HORIZON. The result may raise concerns for other class drugs in phase 3, including Amgen’s and Eli Lilly’s. The trial enrolled over 8,000 participants, and Novartis also faces a steep Entresto patent cliff.

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