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Novartis’ Del-Desiran Fails Phase 3 in Myotonic Dystrophy Type 1 Trial

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Novartis’ investigational del-desiran, acquired via its $12B Avidity deal, failed in the Phase 3 HARBOR study for myotonic dystrophy type 1. The antibody-oligonucleotide conjugate did not significantly improve hand opening time versus baseline. Separately, pelacarsen also failed a Phase 3 cardiovascular-risk study, adding pressure on the pipeline.

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