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Novartis and BMS Freeze CAR T Autoimmune Trials After Safety Signals

Bristol-Myers Squibb logoBristol-Myers Squibb
Sig2.25Sen-3.10Env0.00Soc-2.60Gov-0.70
Novartis logoNovartis
Sig3.25Sen-5.20Env0.00Soc-4.85Gov-2.30

Novartis paused several trials of its CAR T rapcabtagene autoleucel in autoimmune disease after three patient deaths. Bristol Myers Squibb followed by voluntarily freezing autoimmune trials for its CAR T zolacabtagene autoleucel after observing transient and reversible inflammatory events. Elsewhere, Revolution Medicines gained early FDA approval for its pancreatic cancer drug Rasonque, while other clinical trials reported futility or failure.

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