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Moderna’s Intismeran Personalized mRNA Vaccine Cuts Cancer Recurrence Risk

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Moderna’s intismeran trial in melanoma patients whose tumors were fully removed reported late-stage success. By sequencing individual tumor mutations to select up to 34 neoantigens and pairing personalized mRNA immunotherapy with KEYTRUDA, the study found a 49% lower risk of recurrence or death and a 59% lower risk of distant metastasis in patients. Success builds on earlier data and highlights the need for cross-company collaboration with Merck and sequencing support from Personalis.

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