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Merck Forges Growth Path With Pipeline to Offset Keytruda LOE

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Merck relies on a growing pipeline and an expanding portfolio of newer medicines, including acquired assets, to offset the eventual loss of exclusivity for Keytruda. The drug generated $16.40B in first-half 2026 sales, up nearly 4.2% year over year. With Keytruda’s LOE expected in 2028, Merck expects pipeline and potential new blockbusters to drive the next phase of growth.

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