FDA grants Breakthrough Therapy designation to Lilly’s olomorasib for pancreatic cancer
FDA awarded Breakthrough Therapy designation to Eli Lilly’s investigational KRAS G12C inhibitor olomorasib for previously treated advanced pancreatic cancer in patients with KRAS G12C mutations. The designation comes amid a lack of KRAS G12C–targeted therapies, with metastatic pancreatic cancer carrying a five-year survival rate below 5% and substantial ongoing mortality in the U.S.