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BioNTech Drops 8% After Colorectal Cancer Vaccine Trial Is Scrapped

BioNTech logoBioNTech
Sig2.98Sen-1.20Env0.00Soc+0.50Gov+0.23
Moderna logoModerna
Sig1.75Sen-1.35Env0.00Soc0.00Gov0.00
Pfizer logoPfizer
Sig2.97Sen+3.34Env0.00Soc+1.94Gov+1.30

BioNTech’s shares fell about 8% after the company ended its Phase 2 BNT122-01 colorectal cancer vaccine study for futility, after crossing a boundary flagged in October 2025. The trial of an mRNA vaccine developed with Genentech tested adjuvant monotherapy in patients with surgically resected high-risk Stage II/III disease, ending a high-profile oncology program in its post-COVID pivot.

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