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Arrowhead Presents Phase 3 SHASTA-3/4 Results Showing Plozasiran Cuts Pancreatitis Events

Arrowhead Pharmaceuticals logoArrowhead Pharmaceuticals
Sig2.90Sen+3.00Env0.00Soc+1.90Gov+0.10

Plozasiran lowered triglycerides by 79% and 81% versus placebo in SHASTA-3 and SHASTA-4 across severe hypertriglyceridemia patients, with most reaching below acute pancreatitis risk thresholds by Month 12. Cumulative acute pancreatitis events fell 78% versus placebo, including a 100% reduction in the highest-risk subgroup. Results came from global Phase 3 trials in adults treated subcutaneously every three months.

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