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Amgen’s 7,297-Patient Trial Faces a Higher Proof Bar After Pelacarsen Loss

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Amgen’s OCEAN(a) outcomes study has finished enrolling 7,297 participants and is tracking coronary-heart-disease deaths, heart attacks, and urgent coronary procedures over about five years. A rival Lp(a) drug lowered lipoprotein(a) but failed to reduce major cardiovascular events in a Phase 3 trial, raising the standard that investors may have assumed from lab improvements.

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