Akeso’s ivonescimab shows OS and PFS gains over Merck’s Keytruda in China trial
Akeso reported interim Phase 3 HARMONi-2 results in China showing its ivonescimab PD-1/VEGF bispecific improved overall survival and progression-free survival versus Merck’s Keytruda in first-line NSCLC with PD-L1–expressing tumors. The data builds on prior PFS success. Analysts note the global HARMONi-3 trial will be critical, with concerns about FDA accelerated approval impact if benefits aren’t sufficient.