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Akeso and Summit Phase III shows ivonescimab survival edge over Keytruda

Summit Therapeutics logoSummit Therapeutics
Sig3.65Sen+6.85Env0.00Soc+4.20Gov+1.40
Merck logoMerck
Sig3.35Sen-2.60Env0.00Soc0.00Gov0.00

Akeso and Summit Therapeutics said ivonescimab improved overall survival for non-small cell lung cancer in the randomized Phase III HARMONi‑2 trial, beating Merck’s Keytruda, which had been the global standard for nearly a decade. Ivonescimab also delayed progression at 11.14 months vs 5.82 and targets PD‑1 and VEGF; additional HARMONi‑3 and a US EGFR-mutant approval decision are pending for 2026 and 14 Nov.

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